Microbiological reduction of 15-ketoprostaglandin intermediates

US4247635A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Klaus Kieslich · Braunschweig, DE
• Bernd Raduchel · Berlin, DE
• Werner Skubalia · Berlin, DE
• Helmut Vorbruggen
• Helmut Dahl · Berlin, DE

Key dates

• Filing date: Dec 5, 1979
• Grant date: Jan 27, 1981
• Expiry date: Dec 5, 1999

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/941
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process for the preparation of a 15 .alpha.-hydroxyprostaglandin intermediate of the formula ##STR1## wherein R.sub.1 is phenoxymethyl, phenoxymethyl substituted on the phenyl moiety by halogen or trifluoromethyl, or alkyl of 1-5 carbon atoms, and PA1 R.sub.2 is hydrogen, acetyl, benzoyl or p-phenylbenzoyl, which comprises stereospecifically microbiologically reducing a corresponding 15-ketone of the formula ##STR2## with a strain of the microorganism Kloeckera, Saccharomyces or Hansenula.