Preparation of stabilized carrier-bound proteins

US4247643A · kind A · utility

Assignee

• Rohm GmbH Chemische Fabrik · DE

Inventors

• Dieter Kramer · Lindlar, DE
• Klaus Sauber · Schwalbach, DE

Key dates

• Filing date: Jul 13, 1978
• Grant date: Jan 27, 1981
• Expiry date: Jul 13, 1998

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/816
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Stabilized carrier-bound protein is prepared by reacting a protein in aqueous solution with a mercapto group free, water insoluble carrier which contains binding groups which are reactive with the said protein and reacting the resultant protein-containing mercapto group-free carrier with hydrogen sulfide or with a compound having a molecular weight of less than 5000, and which contains at least two mercapto groups, or at least one mercapto group and at least one hydroxy- group or primary or secondary amino group.