Process for producing an antihemophilic factor preparation from human blood plasma by irradiating with electromagnetic waves
US4251437A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 26, 1979 |
| Grant date | Feb 17, 1981 |
| Priority date | — |
| Expiry date | Oct 26, 1999 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/83
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An antihemophilic factor preparation (AHF) of high solubility and long half-life is produced in high yields by complete or partial thawing of deep-frozen human blood plasma by irradiation with electromagnetic waves of a frequency of about 10.sup.8 -10.sup.15 for a period of time and with an energy penetration such that the temperature in the thawed plasma does not exceed 10.degree. C. at any point, and processing in a manner known per se by centrifuging the thawed product to form a cryoprecipitate, redissolving the cryoprecipitate in a buffer and isolating a concentrated solution which, if desired, is freeze-dried. Irradiation is preferably effected by microwaves of a frequency of 10.sup.8 -3.times.10.sup.11 Hz, in particular 2.times.10.sup.9 -3.times.10.sup.10 Hz, or by infrared light, said frozen plasma being preheated if desired. The preparation is suitable for injection performed by the patient himself without medical assistance.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.