Phthalazin-4-ylacetic acid derivatives
US4251528A · kind A · utility
32Cited by
1References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 29, 1978 |
| Grant date | Feb 17, 1981 |
| Priority date | — |
| Expiry date | Nov 29, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D493/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to enzyme inhibitory, novel phthalazin-4-ylacetic acid derivatives of the general formula I: ##STR1## and pharmaceutically acceptable salts as appropriate, to pharmaceutical compositions thereof, and to analogy processes for their manufacture. The compounds of formula I are inhibitors of the enzyme aldose reductase in vivo and as such may be useful in the reduction or prevention of the development of the peripheral effects such as macular oedema, cataract, retinopathy or impaired neural conduction. A preferred compound is 2-(2-fluoro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazin-4-ylacetic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.