Amino derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazoles

US4251539A · kind A · utility

Assignee

• BASF SE

Inventors

• Peter C. Thieme · Monsheim, DE
• Fritz-Frieder Frickel · Ludwigshafen, DE
• Hans Theobald · Schifferstadt, DE
• Albrecht Franke
• Dieter Lenke · Ludwigshafen, DE
• Josef Gries · Monsheim, DE

Key dates

• Filing date: Apr 17, 1979
• Grant date: Feb 17, 1981
• Expiry date: Apr 17, 1999

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula ##STR1## where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.