Phenol ethers

US4252984A · kind A · utility

Assignee

• Synthelabo · FR

Inventors

• Philippe Manoury · L'Haÿ-les-Roses, FR
• Icilio Cavero · Créteil, FR
• Henry Najer · Paris, FR
• Don Pierre Rene Lucien Giudicelli · Fontenay-sous-Bois, FR

Key dates

• Filing date: Oct 20, 1976
• Grant date: Feb 24, 1981
• Expiry date: Oct 20, 1996

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides phenol ethers of the formula: ##STR1## wherein R is branched C.sub.3-4 alkyl, C.sub.3-4 cycloalkyl, branched cyano(C.sub.3-4 alkyl), phenyl(C.sub.2-3 alkyl), halophenyl(C.sub.2-3 alkyl), (C.sub.1-4 alkoxy)phenyl(C.sub.2-4 alkyl), or (C.sub.1-4 acyl)amino(C.sub.1-4 alkyl), PA1 alk is C.sub.1-4 alkyl substituted by a 3 to 6 membered cycloalkyl group, PA1 X is --O--, --S-- or --SO.sub.2 --; and PA1 R.sub.1 is --C.sub.1-4 alkyl- or --C.sub.1-4 alkoxy-, in their racemic and optically active forms, and their addition salts with pharmaceutically acceptable acids. These compounds are useful in therapy as .beta.-adrenergic blocking agents. Intermediates are also provided.