Patent · US Expired

Peptides related to somatostatin

US4253998A · kind A · utility

36Cited by
7References
9Claims
0Family size

Assignee

Inventor

Key dates

Filing dateMar 9, 1979
Grant dateMar 3, 1981
Priority date—
Expiry dateMar 9, 1999

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY10S930/16
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Peptides of the formula: ##STR1## wherein: X is H, --NH.sub.2, --NH--Gly--Ala, --NH--D--Ala--Ala, --NH--Gly--Gly--Gly, --NH--acetyl, or --NH--benzoyl; PA1 X.sub.1 is His or Arg; PA1 X.sub.2 is His, Glu, Tyr, Trp, or Phe; PA1 X.sub.3 is Trp, D-Trp, or 6-F-D-Trp; and PA1 X.sub.4 is a D-.alpha.-amino acid; or the reduced, linear form thereof, or a non-toxic, pharmaceutically acceptable acid addition salt thereof; inhibit the release of growth hormone, insulin, and glucagon; and show prolonged inhibition activity. Said peptides are prepared by solid-state methodology.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.