Triazine derivatives
US4254122A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | May 7, 1979 |
| Grant date | Mar 3, 1981 |
| Priority date | — |
| Expiry date | May 7, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D251/46
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns new analgesic 6-acylaminotetrahydro-1,3,5-triazine-2,4-dione derivatives of the formula: ##STR1## in which R.sup.1 is an optionally substituted phenyl, phenyl- (1-4C)alkyl, naphthyl, monocyclic or bicyclic heteroaromatic or (monocyclic or bicyclic heteroaromatic)- (1-4C)alkyl radical, R.sup.2 is a (3-8C)cycloalkyl, [(3-8C)cycloalkyl]-(1-4C)alkyl or (3-6C)alkenyl radical, or an optionally substituted phenyl or phenyl- (1-4C)alkyl radical, and R.sup.3 is a (1-4C)alkyl radical, preferably a methyl radical; together with pharmaceutically acceptable salts thereof. Also provided are processes for the manufacture of, and pharmaceutical compositions of, derivatives of formula I and salts thereof. Some of the derivatives of formula I possess anti-inflammatory properties and/or are inhibitors of the enzyme prostaglandin synthetase in addition to possessing analgesic properties. A typical compound of the invention is 3-(thien-2-yl)-6-[(N-acetyl)isobutylamino]tetrahydro-1,3,5-triazine-2,4-di one.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.