Topical application of prostaglandin hypotensive agents
US4254145A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 16, 1978 |
| Grant date | Mar 3, 1981 |
| Priority date | — |
| Expiry date | Aug 16, 1998 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Pharmaceutical compositions useful as vasodilators whose activity may be restricted to the site of application by control of the dose applied which comprises a prostaglandin selected from the group consisting of the natural and synthetic analogs of the PGE, PGA and PGE.sub..beta. types in a pharmaceutical carrier. The compositions are applied topically and by local injection to increase peripheral circulation, or to treat peripheral vascular disorders of the arteriospastic and occlusive types. The prostaglandins and pharmaceutical compositions containing them disclosed herein are also administered topically and by local injection to lower the systemic blood pressure of man and warm blooded animals. Systemic action is obtained by the use of an effective dosage greater than that used to induce localized action at the site of application.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.