Furan derivatives having selective action on histamine receptors

US4255440A · kind A · utility

Assignee

• Allen & Hansburys Limited · GB

Inventors

• Barry J. Price · London, GB
• John W. Clitherow · Sawbridgeworth, GB
• John Bradshaw · Solon, US

Key dates

• Filing date: Oct 13, 1978
• Grant date: Mar 10, 1981
• Expiry date: Oct 13, 1998

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/64
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the general formula I: ##STR1## and physiologically acceptable salts thereof and N-oxides and hydrates, in which R.sub.1 and R.sub.2 which may be the same or different represent hydrogen, lower alkyl, cycloalkyl, lower alkenyl, aralkyl or lower alkyl interrupted by an oxygen atom or a group ##STR2## in which R.sub.4 represents hydrogen or lower alkyl or R.sub.1 and R.sub.2 may, together with the nitrogen atom to which they are attached, form a heterocyclic ring which may contain other heteroatoms selected from O and ##STR3## R.sub.3 is hydrogen, lower alkyl, lower alkenyl or alkoxyalkyl; X is --CH.sub.2 --, O-- or --S--; PA1 Y represents .dbd.S, .dbd.O, .dbd.NR.sub.5 or .dbd.CHR.sub.6 ; PA1 Alk denotes a straight or branched alkylene chain of 1 to 6 carbon atoms; PA1 R.sub.5 is H, nitro, cyano, lower alkyl, aryl, alkylsulphonyl, or arylsulphonyl; PA1 R.sub.6 represents nitro, arylsulphonyl or alkylsulphonyl; PA1 m is an integer from 2 to 4; and PA1 n is 1 or 2; or when X is --S-- or --CH.sub.2 --, n is zero, 1 or 2. These compounds have H.sub.2 -antagonist activity. Intermediates in the production thereof are also provided.