Synthesis and use of diagnostic radio-pharmaceuticals comprising radioactive isotopes of bromine with dyes
US4256727A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 18, 1978 |
| Grant date | Mar 17, 1981 |
| Priority date | — |
| Expiry date | Sep 18, 1998 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for preparing bromine-containing dyes labelled with gamma-emitting isotopes of bromine, and the product thereof which is useful as an imaging agent for the hepato-biliary system, particularly in dynamic imaging methods. The dyes prepared are from the class of triarylmethane dyes, and also from the phthalein subclass of the class of xanthene dyes, and the labelling thereof is effected with .sup.76 Br, .sup.77 Br or .sup.82 Br. The process for preparing these dyes involves reacting the non-brominated dye precursor with either .sup.76 Br.sub.2, .sup.77 Br.sub.2 or .sup.82 Br.sub.2. This is a substitution type of reaction in which a ring hydrogen is substituted by either .sup.76 Br, .sup.77 Br or .sup.82 Br.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.