9-(.omega.-Heteroarylamino-alkylamino)-erythromycins and salts thereof

US4256738A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Eberhard Woitun · Biberach an der Riß, DE
• Bernd Wetzel · Biberach an der Riß, DE
• Roland Maier · Biberach an der Riß, DE
• Wolfgang Reuter
• Uwe Lechner · Biberach an der Riß, DE
• Rolf Werner · Ludwigshafen, DE
• Hanns Goeth · Biberach an der Riß, DE

Key dates

• Filing date: Nov 3, 1978
• Grant date: Mar 17, 1981
• Expiry date: Nov 3, 1998

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula EQU R--NH--(CH.sub.2).sub.n --NH--E wherein PA0 R is a pyrimidinyl, a quinazolinyl, a 5,6,7,8-tetrahydro-quinazolinyl, a thieno[3,2,-d]pyrimidinyl, a thieno[2,3-d]pyrimidyl, a pyrido[3,2-d]primidinyl, a 5,6-dihydro-4-pyrido[3,4-d]pyrimidinyl, an isothiazola [5,4-d]pyrimidinyl or a pyrimido[4,5-d]-pyrimidinyl group; PA0 n is 2 or 3; and PA0 E is the 9-erythromycyl group; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antibacterials.