Process for the preparation of 1-(2-tetrahydrofuryl)-5-fluorouracil
US4256885A · kind A · utility
0Cited by
2References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 10, 1976 |
| Grant date | Mar 17, 1981 |
| Priority date | — |
| Expiry date | Dec 10, 1996 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for efficiently preparing 1-(2-tetrahydrofuryl)-5-fluorouracil useful as an antitumor agent or an antiviral agent which comprises reacting 5-fluorouracil with 2,3-dihydrofuran. This reaction proceeds advantageously in the presence of a reaction accelerator such as a Lewis acid in a polar solvent such as pyridine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.