Phenoxy-amino-propanols

US4258062A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rochus Jonas · Darmstadt, DE
• Karl-Heinz Becker · Darmstadt, DE
• Hans-Joachim Enenkel · Darmstadt, DE
• Klaus-Otto Minck · Ober-Ramstadt, DE
• Hans-Jochen Schliep · Traisa, DE

Key dates

• Filing date: May 30, 1979
• Grant date: Mar 24, 1981
• Expiry date: May 30, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D303/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

New phenoxy-amino-propanols of formula ##STR1## wherein R.sup.1 is alkenyl, alkynyl, alkoxyalkyl or alkenyloxyalkyl with 2-6 C atoms in each case or cycloalkyl with 3-8 C atoms; and R.sup.2 is alkyl or hydroxyalkyl with 1-6 C atoms in each case, cycloalkyl with 3-8 C atoms, aralkyl or aralkyl wherein the aryl radical is mono- to tri-substituted by alkyl, alkoxy, OH, F and/or Cl or mono-substituted by methylenedioxy, with a total of 7-15 C atoms in each case, and the physiologically acceptable acid addition salts thereof, exhibit various pharmacological properties including isoprenaline-antagonism on the heart rate and blood pressure.