4-Hydroxy-2H-[1]-benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxides and salts thereof

US4259336A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Wolfhard Engel
• Gunter Trummlitz · Warthausen, DE
• Ernst Seeger · Biberach, DE
• Walter Haarmann
• Gunther Engelhardt
• Rainer Zimmermann · Mittelbiberach, DE

Key dates

• Filing date: Oct 22, 1979
• Grant date: Mar 31, 1981
• Expiry date: Oct 22, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/70
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen or alkyl of 1 to 3 carbon atoms; R.sub.2 is hydrogen or alkyl of 1 to 3 carbon atoms; and PA1 R.sub.3 is aromatic hydrocarbyl of 6 to 10 carbon atoms or an aromatic heterocycle of 2 to 9 carbon atoms and 1 to 2 nitrogen atoms and/or an oxygen or a sulfur atom, where each of said aromatic substituents may in turn be substituted with one or two alkyls of 1 to 6 carbon atoms, halogen, hydroxyl, trifluoromethyl, halophenyl or alkoxy of 1 to 3 carbon atoms; and non-toxic, pharmacologically acceptable salts thereof formed with inorganic or organic bases; the compounds as well as their salts are useful as analgesics, antipyretics, antithrombotic and antiphlogistics.