Process for the production of urokinase in pure condition
US4259447A · kind A · utility
21Cited by
3References
35Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 29, 1979 |
| Grant date | Mar 31, 1981 |
| Priority date | — |
| Expiry date | Jun 29, 1999 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/815
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
There is provided a process for the production of pure, concentrated urokinase starting from a crude urokinase solution. The crude urokinase solution is contacted in a medium having a pH of .gtoreq.6 with a porous solid matrix having a high specific surface area on whose surface there is immobilized aprotinin. Subsequently the urokinase adsorbed in this manner is eluted in an elution agent having a pH.ltoreq.4.5. There are obtained highly concentrated and very pure solutions of urokinase. The urokinase is used in medicine as a pharmaceutical for the dissolving of fibrinous clots and coagulums.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.