Method for increasing antibacterial effectiveness of a .beta.-lactam antibiotic
US4260598A · kind A · utility
6Cited by
10References
6Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Oct 22, 1979 |
| Grant date | Apr 7, 1981 |
| Priority date | — |
| Expiry date | Oct 22, 1999 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
6-Aminopenicillanic acid 1,1-dioxide, esters thereof readily hydrolyzable in vivo, and the pharmaceutically-acceptable salts of these compounds, are useful for enhancing the effectiveness of certain .beta.-lactam antibiotics against certain .beta.-lactamase producing bacteria. Derivatives of 6-aminopenicillanic acid 1,1-dioxide protected by a conventional carboxy protecting group are useful intermediates to 6-aminopenicillanic acid 1,1-dioxide and esters thereof readily hydrolyzable in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.