Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same
US4260605A · kind A · utility
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9Claims
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Key dates
| Filing date | Jan 14, 1980 |
| Grant date | Apr 7, 1981 |
| Priority date | — |
| Expiry date | Jan 14, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J41/0088
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to novel 21-alkylated steroids of the pregnane series having the formula: ##STR1## wherein R.sub.1 =alkyl (1-4 C); R.sub.2 =carboxyacyl (1-18 C); X=H, F or Cl; Y=O, H(OH), H(lower acyloxy), H(F) or H(Cl) with the proviso that Y is not H(F) when X is F; and the dotted line indicates the optional presence of a double bond, to processes for their preparation and to pharmaceutical compositions containing same. The novel compounds possess strong anti-inflammatory properties, when applied locally and cause little or systemic, thymolytic, adrenolytic and salt-retaining effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.