Isoquinoline aldehydes

US4260763A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Wilhelm Bartmann
• Elmar Konz · Kelkheim, DE
• Hansjorg Kruse · Kelkheim, DE

Key dates

• Filing date: Mar 14, 1979
• Grant date: Apr 7, 1981
• Expiry date: Mar 14, 1999

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Isoquinoline-4-aldehydes of the formula ##STR1## in which X denotes bromine or chlorine, R.sub.1 is phenyl optionally mono- or disubstituted by halogen, hydroxy, nitro, amino, or amino substituted by one or two aliphatic, cycloaliphatic or aromatic hydrocarbon radicals having from 2 to 18 carbon atoms, the nitrogen atom possibly being included in a heterocyclic ring, acyl amino, alkyl or alkoxy each having from 1 to 6 carbon atoms, benzoyloxy, or trifluoromethyl, or is pyridyl or thienyl; PA1 R.sub.2 is hydrogen, halogen, hydroxy, alkyl or alkoxy having from 1 to 6 carbon atoms, nitro, amino, benzyloxy, methylene dioxy or ethylene dioxy and PA1 m is 1 or 2; which are effective in the treatment of spasms and as tranquilizers.