X-ray contrast media

US4264572A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Erich Klieger · Berlin, DE
• Wolfgang Mutzel · Berlin, DE

Key dates

• Filing date: Nov 30, 1979
• Grant date: Apr 28, 1981
• Expiry date: Nov 30, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C233/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 is C.sub.1-4 alkyl, C.sub.1-4 alkyl substituted by OH or C.sub.1-2 alkoxy; R.sub.2, R.sub.3 and R.sub.4 are independently each hydrogen or C.sub.1-4 alkyl; Z is --A--NHCH.sub.3 or when R.sub.1 is hydroxy or alkoxy substituted alkyl and/or when R.sub.3 is lower alkyl, Z can also be hydroxy-C.sub.2-5 -alkylamino; PA0 R.sub.5 is C.sub.1-4 alkyl or C.sub.1-4 alkyl substituted by OH; n is 1, 2 or 3; and A is: ##STR2## wherein R.sub.7 is H or C.sub.1-4 alkyl; R.sub.8 is H, C.sub.1-4 alkyl or C.sub.1-4 alkyl substituted by OH or C.sub.1-2 alkoxy; or together R.sub.7 and R.sub.8 form a propylene or hydroxypropylene ring; and m is 0 or 1; PA0 or an ester thereof with a C.sub.1 -C.sub.4 alkanol or a physiologically acceptable salt thereof with a base, are valuable as X-ray contrast media.