Patent · US Expired

Method of making genetically stable mutants of vibrio cholerae

US4264737A · kind A · utility

10Cited by
3References
6Claims
0Family size

Assignee

Inventor

Key dates

Filing dateJul 20, 1979
Grant dateApr 28, 1981
Priority date—
Expiry dateJul 20, 1999

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY10S435/909
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Incubation of a parent strain of Vibrio cholerae at elevated temperature to produce a hypotoxinogenic variant strain and mutation of the variant strain results in mutant strains which retain the biotype and antigens of the parent strain, and which are genetically stable and useful as live oral vaccines for immunization against cholera. Preferably, a hypotoxinogenic mutant which is also non-pathogenic in animal model systems is isolated by the method disclosed in this application.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.