Chromatographic separation and quantitative analysis of ionic species
US4265634A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 10, 1980 |
| Grant date | May 5, 1981 |
| Priority date | — |
| Expiry date | Mar 10, 2000 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/965
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Method and apparatus for chromatographic separation and quantitative analysis of ions of like charges in a sample, e.g., cations or anions. For the analysis of inorganic anions, the sample and an eluent are directed to a hydrophobic chromatographic separation bed without permanently attached ion exchange sites. The eluent (a polar mobile liquid) includes an organic cation which reversibly adsorbs to the bed to create ion exchange sites which differentially retard the anions for chromatographic resolution. The eluent also includes a developing reagent of the same charge as the ion to be analyzed. The eluent including the resolved anions is then passed through an ion exchange resin which precludes passage of the counter ion and its co-ion in ionized form and then through a conductivity cell for quantitative detection. Inorganic cations may be detected in an analogous manner. The system may also be employed to analyze highly organic cations or anions (e.g., surfactants). In this instance, the organic ion of interest is already strongly attracted to the hydrophobic separation bed, and so the counter ion may be inorganic.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.