Conversion of carboxamide to N-substituted derivative thereof using carbon magnetic analysis
US4265835A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1979 |
| Grant date | May 5, 1981 |
| Priority date | — |
| Expiry date | Sep 10, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F8/32
- WIPO fieldMacromolecular chemistry, polymers
- WIPO sectorChemistry
Abstract
In a process for preparing a N-substituted derivative of a carboxamide, the conversion of carboxamide to the derivative is determined by carbon-13 nuclear magnetic resonance analysis (CMR) wherein the intensities of the carbonyl carbon peaks attributable to the carboxamide and the derivative are measured under conditions of magnetic resonance and the mole ratio of carboxamide to derivative is determined by comparing the intensities of said carbonyl carbon peaks. For example, in the reaction of polyacrylamide with a secondary amine such as dimethylamine and formaldehyde, the conversion of the polyacrylamide to its N-(dimethylaminomethyl) derivative is determined by subjecting the sample to CMR analysis and comparing the intensities of the carbonyl carbon peaks of the polyacrylamide and the N-(dimethylaminomethyl) derivative.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.