Monophosphonate compounds as hypoglycemic and/or antiartherogenic agents
US4268507A · kind A · utility
7Cited by
2References
8Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 30, 1980 |
| Grant date | May 19, 1981 |
| Priority date | — |
| Expiry date | Jan 30, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4025
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to new monophosphonate compounds of formula X--C.sub.6 H.sub.4 --(O).sub.m --(CH.sub.2).sub.n --R where R is --PO.sub.3 Me.sub.2, --PO.sub.3 Et.sub.2, --PO.sub.3 H.sub.2 or --PO.sub.3 Na.sub.2, X is a halogen, preferably chlorine, in position o, m or p, preferably in position p; m is 0 or 1; and n is 0, 1, 2, 3, 4, 5 or 6, which possess remarkable activity as hypoglycemic and/or antiatherogenic agents, and are usable in pharmaceutical compositions to alter lipoprotein profiles in favor of high density lipoproteins and to clear cholesterol from various tissues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.