Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4268672A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 5, 1979 |
| Grant date | May 19, 1981 |
| Priority date | — |
| Expiry date | Jan 5, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65616
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The preparation of (.+-.)-9-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl)cycl opentyl)]-6-substituted purines: ##STR1## and (.+-.)-3-[.alpha.-(2.alpha.,3.beta.-dihydroxy-4.alpha.-(hydroxymethyl)cycl opentyl)]-7-substituted-v-triazolo[4,5d]pyrimidines: ##STR2## and their derivatives wherein R is amino, mercapto, methylmercapto, hydroxy, halogen, or substituted amino: ##STR3## wherein R' and R" may be the same or different and are of hydrogen, methyl, ethyl, propyl or phenyl. The preparation of the single intermediate from which either of these series of compounds may be synthesized is also disclosed. The compounds exhibit antiviral and antitumor activity. Acid salts and esters of the purine nucleosides have also been prepared.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.