Asymmetric hydroformylation process
US4268688A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 16, 1973 |
| Grant date | May 19, 1981 |
| Priority date | — |
| Expiry date | Feb 16, 1993 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2531/827
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a process for the preparation of optically active aldehydes by the asymmetric catalytic hydroformylation of olefins. The process comprises the hydroformylation of olefinically unsaturated prochiral compounds in the presence of an optically active coordination compound containing a metal which is selected from the group consisting of rhodium, iridium, and cobalt. This invention describes a generalized process for the asymmetric hydroformylation of a wide variety of olefins in which a preponderance of one optical isomer is produced. It is especially useful for the preparation of natural products which may require the presence of only one optical isomer for their utilization, for example, as flavors, fragrances, and medications. The catalyst systems for the process of this invention are formed in the presence of carbon monoxide and hydrogen, from coordination compounds consisting of a central metal atom, rhodium, iridium, or cobalt, and at least one optically active ligand, e.g., phosphine, arsine, stibine, or amine. The coordination compound may contain one or more additional ligands, which may be neutral or which may possess negative charges such as carbon …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.