Physiological preparation containing loaded cells in suspension and a magnetic agent for local concentration thereof in a living body

US4269826A · kind A · utility

Assignee

• Kernforschungsanlage Lulich Gesellschaft mit beschrankter Haftung · DE

Inventors

• Ulrich Zimmermann · Waldbrunn, DE
• Gunter Pilwat · Jülich, DE

Key dates

• Filing date: Dec 12, 1977
• Grant date: May 26, 1981
• Expiry date: Dec 12, 1997

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K35/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Magnetic substances in particles of a diameter in the range between 1 and 20 nm are suspended in the physiological solution by which cells are loaded with materials when their cell membranes have increased permeability, the magnetic materials being provided in such dosing, that when the cells are loaded, separated from the loading solution and prepared for use in a fresh physiological solution, thereafter injected to a living body, they can be collected and held fast at a predetermined location, for example, at the location of a tumor, by the effect of an external magnetic field. Ferritin, magnetite, cobalt ferrite, nickel ferrite and other ferrimagnetic, ferromagnetic or even paramagnetic compounds can be incorporated into loaded cells for this purpose.