(3-Alkylamino-2-hydroxypropoxy)-furan-2-carboxylic acid anilides and physiologically tolerated acid addition salts thereof and medicaments containing them

US4269855A · kind A · utility

Assignee

• A NATTERMANN & CIE GMBH · DE

Inventors

• Joachim Uhlendorf · Lechenich, DE
• Hans Betzing · Kerpen, DE
• Hamied Gabbar · Lechenich, DE
• Erich Graf · Kerpen, DE
• Ille-Stephanie Doppelfeld · Cologne, DE

Key dates

• Filing date: Jun 3, 1980
• Grant date: May 26, 1981
• Expiry date: Jun 3, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D307/71
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

(3-Alkylamino-2-hydroxypropoxy)-furan-2-carboxylic acid anilides of the formula: ##STR1## in which R.sub.1 denotes a straight or branched C.sub.1 to C.sub.5 alkyl group or a cyclopropyl or cyclopentyl group, R.sub.2 denotes a hydrogen or halogen atom or a methyl, methoxy, nitro or acetyl group, R.sub.3 denotes a hydrogen or halogen atom or a nitro group and A denotes a single bond or the --CH.sub.2 -- or --CH.dbd.CH-- group, and physiologically tolerated acid addition salts thereof possess .beta.-adrenolytic properties and a low toxicity.