N1-Benzoyl-N2-phenyldiaminopropanols and pharmaceutical compositions thereof, and processes for their preparation

US4271193A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Hans Liepmann · Hannover, DE
• Rolf Hueschens · Hannover, DE
• Wolfgang Milkowski
• Horst Zeugner
• Henning Heinemann · Hannover, DE
• Klaus-Ulrich Wolf · Burgdorf, DE
• Insa Hell · Hannover, DE
• Reinhard Hempel · Hannover, DE

Key dates

• Filing date: Jun 22, 1979
• Grant date: Jun 2, 1981
• Expiry date: Jun 22, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D319/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

N.sub.1 -benzoyl-N.sub.2 -phenyl-1,3-diaminopropan-2-ols are disclosed which exhibit a stabilizing effect on the gastric mucosa and enhance the stability and resistance of the gastic mucosa against harmful effects caused by, e.g., excessive alcohol consumption or drugs. The compounds are useful in the prophylaxis and treatment of gastritis. Further disclosed are pharmaceutical compositions which are effective in stabilizing the gastric mucosa and in the treatment and proplylaxis of gastritis and which comprise as a pharmacologically active ingredient N.sub.1 -benzoyl-N.sub.2 -phenyl-1,3-diaminopropan-2-ols, or a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutically acceptable diluent. Further disclosed are processes for the preparation of the N.sub.1 -benzoyl-N.sub.2 -phenyl-1,3-diaminopropan-2-ols.