Process for preparing active compounds
US4272445A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 19, 1978 |
| Grant date | Jun 9, 1981 |
| Priority date | — |
| Expiry date | May 19, 1998 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J31/003
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of a compound of the formula (A): ##STR1## wherein: R.sub.3 is a C.sub.1-5 alkyl group, a C.sub.3-6 alkenyl group, a C.sub.3-6 cycloalkyl group or an alkylphenyl group in which the alkyl moiety contains 1 to 3 carbon atoms and the phenyl moiety is optionally substituted; R.sub.4 is a hydroxyl group, or a group OR.sub.6 wherein R.sub.6 is a C.sub.2-7 acyl group, a C.sub.1-4 alkyl group, or an optionally substituted benzyl group; R.sub.5 is hydrogen or a C.sub.1-5 alkyl group; or R.sub.4 and R.sub.5 together with the carbon atom to which they are joined represent a carbonyl group; which process comprises the reaction of a compound of the formula (C): ##STR2## wherein Q is a carbonyl group protected by a reagent capable of selectively protecting the 3-carbonyl of androstenedione, and R.sub.3, R.sub.4 and R.sub.5 are as defined in formula (A), to generate an unprotected carbonyl group in place of the protected carbonyl group Q. This process has advantages over the known process for the preparation of compounds of formula (A).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.