N-Acyl-muramyl peptide derivatives having anti-infectious infections properties

US4272524A · kind A · utility

Assignee

• Agence Nationale de Valorisation de la Recherche · FR

Inventors

• Louis Chedid · Paris, FR
• Jean Choay · Paris, FR
• Edgar Lederer · Sceaux, FR
• Pierre Lefrancier · Les Ulis, FR
• Monique Parant · Paris, FR
• Francine Parant · Paris, FR

Key dates

• Filing date: Nov 1, 1977
• Grant date: Jun 9, 1981
• Expiry date: Nov 1, 1997

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/19
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a new method for increasing the resistance of the organism to pathogenic germs and to compositions to carry out said method. In this method, one administers an effective dose of N-acetyl-muramyl-L-alanyl-D-isoglutamine or analogs responding to the formula ##STR1## wherein R.sub.1 is OH or NH.sub.2, R.sub.2 is OH, NH.sub.2 or a peptidic residue containing from 1 to 6 aminoacids, with the proviso that R.sub.1 and R.sub.2 are not simultaneously NH.sub.2.