7,8 and 7-8 Substituted 4,5.alpha.-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4272541A · kind A · utility
39Cited by
7References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 11, 1979 |
| Grant date | Jun 9, 1981 |
| Priority date | — |
| Expiry date | Jul 11, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D221/28
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed are 7,8 and 7-8 substituted 4,5.alpha.-epoxymorphinan-6-one compounds characterized by the structural formula: ##STR1## In the foregoing formula R.sub.1 may be H or methyl, R.sub.2 is cyclopropylmethyl, cyclobutylmethyl, allyl or tetrahydrofurfuryl, R.sub.3 is H, .beta.-methyl, .beta.-ethyl or .alpha.-ethyl and R.sub.4 is H or .alpha.-methyl. Particular compounds corresponding to the foregoing description are useful as mixed analgesics/narcotic antagonists whereas others have been found to be pure narcotic antagonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.