Inhibition of thromboxane synthetase by 3-(1-Imidazolylalkyl) indoles
US4273782A · kind A · utility
40Cited by
7References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 5, 1980 |
| Grant date | Jun 16, 1981 |
| Priority date | — |
| Expiry date | Mar 5, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D249/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel 3-(1-Imidazolylalkyl)indoles and the pharmaceutically acceptable acid addition salts thereof are disclosed. The novel compounds are useful in selectively inhibiting the action of the thromboxane synthetase enzyme without significantly inhibiting the action of the prostacycline synthetase or cyclooxygenase enzymes and are thus of value as therapeutic agents for the treatment of ischaemic heart disease, stroke, transient ischaemic attack, thrombosis, migraine and the vascular complications of diabetes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.