Lipid lowering alkylene glycols and ester derivatives thereof
US4275068A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 23, 1979 |
| Grant date | Jun 23, 1981 |
| Priority date | — |
| Expiry date | Apr 23, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D213/80
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel alkylene glycol derivatives of the formula (1) ##STR1## in which R.sup.1 is the hydrogen atom, an alkyl group having 1-4 C-atoms or an aryl group, R.sup.2 is the hydrogen atom or an alkyl group having 1-4 C-atoms, R.sup.3 is the hydrogen atom or a group of the formula ##STR2## in which Z is an alkyl residue, an optionally substituted aryl residue or a heterocyclic residue and R.sup.4 is a residue of the formula ##STR3## in which R.sup.5 is the hydrogen atom or chlorine atom, or the methyl group, exhibit an advantageous activity in regard of lowering the cholesterol and triglyceride level in the blood. Production of the novel derivatives by reduction of the corresponding acids, or by reacting a phenol of the formula ##STR4## and an alcohol of the formula ##STR5## optionally with subsequent esterification, is described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.