Method of preparing an intravenously administrable immune globulin preparation containing antibodies and preparations produced according to this method
US4276283A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1979 |
| Grant date | Jun 30, 1981 |
| Priority date | — |
| Expiry date | Sep 10, 1999 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/83
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of preparing an intravenously administrable immune globulin preparation containing antibodies, in which human blood plasma is fractionated and an immune-globulin-containing fraction is freed from undesired protein impurities by a single or repeated precipitation with polyethylene glycol, is characterized in that the immune-globulin-containing fraction is subjected in a first purification step prior to the polyethylene glycol precipitation to a treatment with an aqueous solution of a salt of an inorganic acid, and in that at least one of the following purification steps is carried out with polyethylene glycol in the presence of a soluble carbohydrate or a non-protein-precipitating polyol, whereupon the immune globulin freed from protein impurities is precipitated from the remaining solution by water-soluble polymers and is finished in a known manner to the pharmaceutical preparation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.