Determination of serine proteases
US4276375A · kind A · utility
8Cited by
5References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 22, 1979 |
| Grant date | Jun 30, 1981 |
| Priority date | — |
| Expiry date | Oct 22, 1999 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/28
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Serine proteases in a substance such as blood are determined by contacting the substance with a novel chromogenic or fluorgenic substrate for serine proteinases and spectrophotometrically measuring the quantity of a chromophore or fluorescent compound released from the substrate by serine proteases in the substance. The novel substrate has the amino acid sequence-ILe-A-Gly-Arg-wherein A is Asp or Glu substituted in the carboxylic group by esterification or amidation. The novel substrate increases sensitivity and accuracy of the determination.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.