Preparation of 9.alpha.-fluoro-16.alpha.-methyl-21-acetoxy-.DELTA..sup.1,4 -pregnadiene-11.beta.-ol-3,20-dione
US4277409A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 16, 1979 |
| Grant date | Jul 7, 1981 |
| Priority date | — |
| Expiry date | Nov 16, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J13/005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved process for the preparation of pure 9.alpha.-fluoro-16.alpha.-methyl-21-acetoxy-.DELTA..sup.1,4 -pregnadiene-11.beta.-ol-3,20-dione comprising reacting 9.alpha.-fluoro-21-acetoxy-.DELTA..sup.1,4,16 -pregnatriene-11.beta.-ol-3,20-dione with a methyl magnesium halide in the presence of a catalytic amount of a cuprous halide effecting protonation of magnesian to form 9.alpha.-fluoro-16.alpha.-methyl-21-acetoxy-.DELTA..sup.1,4 -pregnadiene-11.beta.-ol-3,20-dione, reacting the raw product with an acetylation agent to acetylate the partially deacetylated product and purifying the reacetylated product with an organic solvent, treating in solution with a peroxidation agent and then purifying again with an organic solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.