Substituted 2-phenylamino-2-imidazolines as bradycardiacs

US4277487A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Helmut Stahle
• Herbert Koppe · Ingelheim am Rhein, DE
• Werner Kummer · Ingelheim am Rhein, DE
• Walter Kobinger · Wien, AT
• Christian Lillie · Wien, AT
• Ludwig Pichler · Wien, AT

Key dates

• Filing date: Jul 17, 1979
• Grant date: Jul 7, 1981
• Expiry date: Jul 17, 1999

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, represent a hydrogen atom, a chlorine atom, or a methyl group, with the proviso that not both R.sub.1 and R.sub.2 are hydrogen, and PA1 R represents a radical selected from the group consisting of --(CH.sub.2).sub.2 --C(CH.sub.3).dbd.CH.sub.2, --(CH.sub.2).sub.2 --CH.dbd.CH.sub.2, --O--CH.sub.2 --CH.dbd.CH.sub.2, --O--(CH.sub.2).sub.2 --CH.dbd.CH.sub.2, --O--CH.sub.2 --C(CH.sub.3).dbd.CH.sub.2, --O--CH.sub.2 --CH.dbd.CH--CH.sub.3, ##STR2## and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.