Preparation of sodium cefuroxime
US4277601A · kind A · utility
2Cited by
3References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 14, 1980 |
| Grant date | Jul 7, 1981 |
| Priority date | — |
| Expiry date | Feb 14, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of the sodium salt of the antibiotic (6R,7R)-3-carbamoyloxymethyl-7-[Z-2-(fur-2-yl)-2-methoxyiminoacetamido]-ce ph-3-em-4-carboxylic acid (cefuroxime) which comprises subjecting a corresponding 3-N-protected carbamoyloxymethyl compound to alcoholysis in a substantially anhydrous medium using a basic catalyst comprising the sodium salt of an acid having a pK.sub.a value of not less than 3.5 whereby sodium cefuroxime or a solvate thereof can be obtained directly without isolation of the corresponding acid. Sodium cefuroxime tetrahydrofuran solvate is also provided as a new entity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.