Papulacandin derivatives and pharmaceutical compositions containing same
US4278665A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 21, 1977 |
| Grant date | Jul 14, 1981 |
| Priority date | — |
| Expiry date | Oct 21, 1997 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/645
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The new antibiotic "Papulacandin" is obtained by the cultivation of the microorganism Papularia sphaerosperma (Pers.) Hohnel, especially of the strain NRRL 8086, under aerobic conditions in an aqueous nutrient medium. There can also be used mutants of said microorganisms. Papulacandin consists of various components A, B, C, D and E, the more important of which are A and B, whose structures have been elucidated to a great extent: they contain only carbon, hydrogen and oxygen. Papulacandin and its components have a strong anti-fungal action, for instance against Candida albicans, and can be used for combating infections caused by pathogenic fungi.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.