Substituted 14-desoxy-mutilin compositions

US4278674A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Helmut Egger · Wien, AT
• Hellmuth Reinshagen · Wien, AT

Key dates

• Filing date: Nov 29, 1979
• Grant date: Jul 14, 1981
• Expiry date: Nov 29, 1999

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C323/58
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to new pleuromutilins of the formula: ##STR1## wherein either R.sub.1 is ethyl or vinyl, PA0 n is an integer from 2 to 5, PA0 x is sulphur, PA0 a group ##STR2## or a group .dbd.N--R.sub.4 .sup.I, wherein either PA0 Y and Z are both sulphur, or PA0 one of Y and Z is oxygen and the other is sulphur, and PA0 R.sub.4.sup.I is hydrogen or a group of the formula: ##STR3## wherein R.sub.1 is as defined above, each of R.sub.2 and R.sub.3 is alkyl of 1 to 10 carbon atoms, or PA0 R.sub.2 and R.sub.3 together with the nitrogen atom form a heterocycle of 5 to 7 ring members containing one nitrogen atom or one nitrogen atom and a further hetero member selected from sulphur, oxygen and a group .dbd.N--R.sub.5.sup.I, PA0 wherein R.sub.5.sup.I is alkyl of 1 to 5 carbon atoms or hydroxyalkyl of 1 to 4 carbon atoms, or PA0 R.sub.2 and R.sub.3 together with the nitrogen atom form a piperazinyl radical, the second nitrogen atom of which is substituted by a radical R.sub.5.sup.II, PA0 whereby R.sub.5.sup.II is (acyloxy of 2 to 5 carbon atoms)alkyl of 1 to 4 carbon atoms or (benzoyloxy)alkyl of 1 to 4 carbon atoms, PA0 or wherein R.sub.1 is as defined above, PA0 n is the number 2,…