Iummunoassay involving agglutination
US4279617A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 26, 1980 |
| Grant date | Jul 21, 1981 |
| Priority date | — |
| Expiry date | Feb 26, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/819
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A particle agglutination assay for antigens, antibodies and other binding proteins such as rheumatoid factor, uses two different, microscopic or submicroscopic particulate reagents. The first particulate reagent binds with the antigen or antibody under assay, and then the second particulate reagent is added which binds only to those first reagent particles which have bound to the antigen or antibody under assay, so causing agglutination. The free unbound first or second particles are assayed to indicate the presence and/or amount of the antigen or antibody under assay. The assay of rheumatoid factor may be so conducted to reveal the fractions of each immunoglobulin class of RF present. The assay is particularly useful for small quantities of antibodies present in human sera indicating allergy, infection or autoimmune diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.