In vivo inhibitors of cholesterol biosynthesis
US4279898A · kind A · utility
6Cited by
2References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 22, 1980 |
| Grant date | Jul 21, 1981 |
| Priority date | — |
| Expiry date | Apr 22, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J9/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Dialkyl esters of 5-carbo[etiocholane-3'.alpha.-7'.alpha., 12'.alpha.-trihydroxy-17'.beta.(1" methyl-4' butyl]oxy-4-hydroxy-4-methylpentyl-1-phosphonate and 5-carbohexadecyloxy-4-hydroxy-4-methylpentyl-1-phosphonate are shown to inhibit cholesterol biosynthesis in rat liver cells. Preparation of the active compounds is given.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.