Process for the production of pancreatin pellets

US4280971A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Martin Wischniewski · Hamburg, DE
• Lutz Feicho · Neustadt, DE
• Gerhard Fischer · Hannover, DE
• Guenter Peschke · Mering, DE

Key dates

• Filing date: Oct 31, 1979
• Grant date: Jul 28, 1981
• Expiry date: Oct 31, 1999

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P1/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pancreatin pellets are produced by a process employing extrusion techniques. In the process, a mixture of pancreatin powder and selected solvent is formed into a pliable mass suitable for extrusion. The extrusion is conducted followed by a cutting, shaping or forming of the extruded mass into pre-pellet like forms. Further drying and mechanical working of the pre-pellet forms results in the final pancreatin pellet of improved pharmaceutical and mechanical stability. A special aspect of the process is the selection of a solvent for mixing with pancreatin powder that is harmless to enzymes. Such solvents typically include isopropanol and acetone.