3-Halo cephalosporins
US4281116A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jul 2, 1980 |
| Grant date | Jul 28, 1981 |
| Priority date | — |
| Expiry date | Jul 2, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D501/59
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
7-Acylamido- and 7-amino-3-halo-3-cephem-4-carboxylic acids, esters and pharmaceutically-acceptable salts and esters thereof are new cephalosporin compounds provided by the reaction of a 7-acylamido-3-hydroxy-3-cephem-4-carboxylic acid ester or a 7-amino-3-hydroxy-3-cephem-4-carboxylic acid ester with an iodinating, fluorinating, chlorinating, or brominating reagent. For example, 7-amino-3-chloro-3-cephem-4-carboxylic acid and 7-phenoxyacetamido-3-chloro-3-cephem-4-carboxylic acid are provided. The 7-acylamido-3-halo cephalosporin acids and pharmaceutically acceptable salts and esters provided are valuable antibiotic compounds having desirable therapeutic properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.