Octapeptides lowering growth hormone
US4282143A · kind A · utility
26Cited by
0References
3Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 13, 1980 |
| Grant date | Aug 4, 1981 |
| Priority date | — |
| Expiry date | Jun 13, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Polypeptides of the formula: ##STR1## in which X.sub.1 is Phe, D-Phe or C.sub.6 H.sub.5 CH.sub.2 CH.sub.2 CO--; PA1 X.sub.2 is Phe, Tyr, Trp, Met or Leu; PA1 X.sub.3 is Trp or D-Trp; PA1 X.sub.4 is Thr, Val, .alpha.-Abu or Phe; and PA1 X.sub.5 is Phe, D-Phe or --NHCH.sub.2 CH.sub.2 C.sub.6 H.sub.5 ; the linear precursor intermediates thereof and pharmaceutically acceptable salts and amides thereof are selective inhibitors of growth hormone release without materially altering blood serum levels of glucagon or insulin. In addition, the above-described compounds are active growth hormone suppressants for periods as long as two hours.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.