Antihypercholesterolemic compounds
US4282155A · kind A · utility
25Cited by
4References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 5, 1980 |
| Grant date | Aug 4, 1981 |
| Priority date | — |
| Expiry date | Aug 5, 2000 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
6(R)-[2-(8'-Etherified-hydroxy-2',6'-dimethylpolyhydronaphthyl-1')-ethyl]-4 (R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones are prepared from the corresponding 8'-acyloxy compounds, some of which are naturally occurring, by protection of the 4(R)-hydroxyl and the 2-keto group, followed by reductive removal of the 8'-acyloxy group, etherification of the resulting 8'-hydroxyl and removal of the protecting groups. The products inhibit the biosynthesis of cholesterol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.