Dithienylpiperidines, pharmaceutical compositions thereof, and method of use thereof

US4283405A · kind A · utility

Assignee

• Degussa AG · DE

Inventors

• Jurgen Engel · Alzenau, DE
• Axel Kleemann · Hanau, DE
• Fritz Stroman · Offenbach, DE
• Klaus Thiemer · Hanau, DE

Key dates

• Filing date: Jan 14, 1980
• Grant date: Aug 11, 1981
• Expiry date: Jan 14, 2000

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

There are prepared compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or together represent a second bond between the carbon atom carrying R.sub.1 and R.sub.2, R.sub.1 also can be a hydroxy group, R.sub.3 is hydrogen, a C.sub.3 -C.sub.8 cycloalkyl group or a C.sub.1 -C.sub.20 alkyl group, which optionally can also contain one or two hydroxy groups and the groups R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are the same or different and are hydrogen, C.sub.1 -C.sub.6 -alkyl groups or halogen atoms, their N-oxide, their quaternary salts and their acid addition salts. There are also described processes for their production. The compounds possess especially an antischemic and blood pressure increasing activity.