Method for manufacturing dipeptides
US4284721A · kind A · utility
16Cited by
2References
10Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Apr 1, 1980 |
| Grant date | Aug 18, 1981 |
| Priority date | — |
| Expiry date | Apr 1, 2000 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0613
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An improvement in a method for manufacturing dipeptides from an N-substituted aspartic acid and a phenylalanine lower alkyl ester. The two starting materials are allowed to react with each other in the presence of an immobilized metallo-proteinase in an organic solvent immiscible with water. The enzyme can be recovered for reuse thereof. The loss of materials due to the hydrolysis of the phenylalanine lower alkyl ester is reduced, so that use of the phenylalanine lower alkyl ester in a nearly stoichiometric quantity suffices for the reaction to ensure an improved yield and reduction in cost of industrial production.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.