Process for the preparation of cephalosporin compounds
US4284766A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 20, 1979 |
| Grant date | Aug 18, 1981 |
| Priority date | — |
| Expiry date | Sep 20, 1999 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65613
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of cephalosporins having a phosphonocarbamoyloxymethyl group at the 3-position by reacting a cephalosporin having at the 3-position a group ##STR1## (wherein R.sup.4 and R.sup.5 are independently alkyl, aralkyl, alicyclic or aryl groups or together form a divalent group) with a compound of formula ##STR2## (wherein R.sup.6, R.sup.7 and R.sup.8 are independently alkyl, aralkyl, alicyclic or aryl groups or any two of R.sup.6, R.sup.7 and R.sup.8 together form a divalent group, and X is halogen) followed by hydrolysis. The 3-phosphonocarbamoyloxymethyl cephalosporin products of the process exhibit antibiotic activity, and if desired may be readily converted to 3-carbamoyloxymethyl cephalosporins which themselves show antibiotic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.